FORMULATION AND EVALUATION OF FLURBIPROFEN TABLET USING SPHERICAL CRYSTALLIZATION FOR SOLUBILITY ENHANCEMENT
AbstractThe present study deals with spherical crystallization of Flurbiprofen crystals in order to improve its flow properties, compressibility and enhancement of dissolution characteristics of drug crystals. Spherical agglomerates of Flurbiprofen prepared by different techniques. Selection of Neutralization technique based on the better percentage yield, drug content, and SEM analysis. Optimization of Flurbiprofen spherical agglomerate was done. The micromeritic properties, solubility, In-vitro drug release of spherical agglomerates were evaluated. Spherical agglomeration enhances the micromeritic and dissolution properties of Flurbiprofen. Optimized formulation of spherical agglomerate was chosen for preparation of tablet. Response surface methodology using Factorial design was chosen for the optimization of spherical agglomerates. Preparation and evaluation of spherical agglomerate tablet and comparing its dissolution characteristics with conventional as well as marketed product. The drug release mechanism from the tablets was found to be case II transport kind of diffusion.
Amidon GL, Lennernas H, Shah VP, et al. A theoretical basis for a bio pharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995; 12: 413-420.
Atul Kumar Gupta, Susheel Kumar Sehrawat Bioavailability enhancement of poorly water soluble drugs International journal of pharmacy & life sciences Vol. 2, Issue 3: March: 2011, 640-650.
Krishnaiah YSR. Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs. J Bioequiv Bioavailab 2010; 2: 28-36.
Kawabata Y, Wada K, Nakatani M, et al. Formulation design for poorly water-soluble drugs based on Biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 2011; 420: 1-10.
Y. Kawashima, M. Imai, H. Takeuchi, H. Yamamoto, K. Kamiya, T. Hino, Improved flowability and compactibility of spherically agglomeratedcrystals of ascorbic acid for direct tableting designed by sphericalcrystallization process. Powder Technology 130 (2003) 283â€“ 289.
Mutalik S, Anju P, Manoj K, Usha AN. Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent change approach. Indian Journal of Pharmaceutical Education and Research. 45(4), (2010), 146â€“252.
S. D. Sawant, A. A. Baravkar, R. N. Kale.FT-IR spectroscopy: principle, technique and mathematics. International Journal of Pharma and Bio Sciences. Vol 2, Issue 1, 2011.
G. T. Kokotailo, C. A. Fyfe.Zeolite structure analysis with powder x-ray diffraction and solid-state nmr techniques. Therigaku journal. vol. 12, no.1 1995.
Gupta, V. R., Mutalik, S., Patel, M. M., &Jani, G. K Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties. Acta pharmaceutica (Zagreb, Croatia), 57(2), (2007). 173â€“84. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17507314.
FaridSetouhy, Bayomi Preparation and Evaluation of Meloxicam Spherical Crystals by Neutralization Technique International Journal of Universal Pharmacy and Bio Sciences May-June 2014 17-20.
NitanBharti, Neeraj Bhandari, Pooja Sharma, Kulwinder Singh, Avneesh Kumar Spherical Crystallization: A Novel Drug Delivery Approach In: Asian journal of bio medical and pharmaceutical sciences Vol.4 (1), 2012. (2013), 57-61.
Chinam NiranjanPatra, Suryakanta Swain, Sauravo Mahanty, Kahnu Charan Panigrahi, Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties. Elsevier Powder Technology 274 (2015) 446â€“454.
U.D Shivhare, V.N Kakade. Formulation and evaluation of a pulsatile delivery system of losartan potassium by factorial design. International journal of pharmaceutical sciences and nanotechnology. 2013; 5 (4): 1895-1901.
Sanjay J Kshirsagar, Shrikant V Patil, Mangesh R Bhalekar. Statistical optimization of floating pulsatile drug delivery system for chronotherapy of hypertension. International Journal of Pharmaceutical Investigation 2011; 1(4): 207 -213.
G. Venugopalarao, R. Lakshmipathy, Ganesh Gadamsetty, N.C. Sarada. Absorption and bioavailability of cefditorenpivoxil in hydrogelsin vitro and in vivo. Journal of Taibah University for Science 9 (2015) 1â€“6.
M K Chourasia, Nitin k Jain, S Jain, N K Jain and S K Jain, Preparation and Characterization of Agglomeration of flurbiprofen by spherical Crystallization Technique. Indian Journal Of Pharmaceutical Science, May- June 2003, 287-290.
International Journal of Pharmaceutics 2008; 350: 279-290. British Pharmacopoeia. The Department of Health, Social Services & Public Safety, London, 2001:12-14.
G. T. Kokotailo, C. A. Fyfe.Zeolite structure analysis with powder x-ray diffraction and solid-state nmrtechniques.Therigakujournal.vol. 12, no.1 1995.
Sateesh K. Vemula, andSanthosh G. Reddy, Formulation and Pharmacokinetics of Flurbiprofen Sublimated FastDissolving Tablets. Open Pharmaceutical Sciences Journal, 2015, 2, 56-65.