EFFECTIVENESS OF INTRADERMAL BOTULINUM TOXIN IN INTRACTABLE POSTHERPETIC NEURALGIA
Abstract
Postherpes neuralgia is not an uncommon complication of herpes. Neuropathic pain is confined to the dermatome supplied by cutaneous nerves. A number of pharmacotherapies and other treatment modalities are tried in treatment of this type of neuralgia; however, still, a sizeable number of patients are refractory to treatment options. Treatment options for such cases is severely limited. Botulinum toxin has been tried recently as one of the treatment option in intractable postherpes neuralgia. In the present report, we have tried botulinum toxin injections in eight patients.ÂReferences
Christo PJ, Hobelmann G, Maine DN. Post-herpetic neuralgia in older adults: evidence-based approaches to clinical management. Drugs Aging. 2007;24(1):1-19.
Argoff CE. Review of current guidelines on the care of postherpetic neuralgia. Postgrad Med. 2011 Sep;123(5):134-42
Chen S, Hui H, Zhang D, Xue Y. The combination of morphine and minocycline may be a good treatment for intractable post-herpetic neuralgia. Med Hypotheses. 2010 Dec;75(6):663-5. Epub 2010 Sep 9.
Young L. Post-herpetic neuralgia: a review of advances in treatment and prevention. J Drugs Dermatol. 2006 Nov-Dec;5(10):938-41.
Puri N. Modified Jaipur block for the treatment of post-herpetic neuralgia. Int J Dermatol. 2011 Nov;50(11):1417-20. doi: 10.1111/j.1365-4632.2011.5083.x.
Jabbari B, Machado D. Treatment of Refractory Pain with Botulinum Toxins-An Evidence-Based Review. Pain Med. 2011 Sep 29. doi: 10.1111/j.1526-4637.2011.01245.x. [Epub ahead of print].
Xiao L, Cheng J, Dai J, Zhang D. Botulinum toxin decreases hyperalgesia and inhibits P2X(3) receptor over-expression in sensory neurons induced by ventral root transection in rats. Pain Med. 2011;12(9):1385-94.
Aoki KR, Francis J. Updates on the antinociceptive mechanism hypothesis of botulinum toxin A. Parkinsonism Relat Disord. 2011 Nov;17 Suppl 1:S28-33
