MICROSHERES – A REVIEW
Abstract
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs also known as microparticles. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. The nasal mucosa has also received attention as a viable means of systemic administration of analgesics, sedatives, hormones, cardiovascular drugs, and vaccines.Keyword: Microspheres, Microparticles, Matrix, Novel drug deliveryReferences
Sworbrik JC et al ;``Encyclopedia of pharmaceutical technologyâ€. Volume-10, Edition,Marcel Dekker, New York (Basel), 1985 :1-29.
Kreuter J et al; `` Microspheres – A Novel Approach in Drug Delivery System.’’ J Pharm sci, 1983; 72: 1146.
Thomas Wai-Yip Lee et al; "Controlled / Release Drug-Delivery Systemsâ€Chapter 47 in 'Remington's Pharmaceutical Sciences', 20th Edition, Mack Publishing Company.2000; 1: 903-929.
Woo B et al†Preparation and characterization of composite PLGA and Poly (acryloyl hydroxyl methyl starch) microsphere system for protein drug deliveryâ€. Pharm. Res.2001; 18: 1600-1606
Paulo Costa et al; ``Modelling and comparison of dissolution profiles, European Journal of Pharmaceutical Science’’, 2001; 13: 123- 133.
Kakar Satinder, Singh Ramandeep, Batra Deepa. Preparation and evaluation of magnetic microspheres of 5-aminosalicyclic acid. Journal of acute disease, 2013;2(3):226-231
Vyas, S. P; “Targeted and Controlled Drug Delivery Novel Carrier Systemâ€, Ist Ed., CBS Publishers and Distributors, New Delhi, 2002 ;417-54.
Jain S.K et al ; ``Calcium silicate based microspheres of repaglinide for gastro-retentive floating drug delivery’’, preparation and in vitro characterization Control Release 2005; 107:300-309
Kakar Satinder, Singh Ramandeep, Batra Deepa. A review on target drug delivery: Magnetic microspheres. Journal of acute disease, 2013;2(3):189-195.
Basak SC,et al; ``Design and in vitro testing of a floatable gastroretentive tablet of metformin Hcl.’’2007; 62(2):145-148.
Patel R Nirav et al; "microsphere as a novel drug delivery, international journal of pharmacy and life science; 2011, 2(8):922-927.
Kataria Sahil et al; " microsphere : a review, international journal of research in pharmacy and chemistry"; 2011; 1(4):1184-1198.
Kakar Satinder et al; " magnetic microsphere as a targetted drug delivery system: an overview; journal of drug delivery research"; 2012; 1(3):1-17.
Kakar Satinder, Singh Ramandeep, Nautiyal Ujjwal, Batra Deepa. Magnetic microspheres as magical novel drug delivery system: A Review. Journal of acute disease, 2013;2(1):1-12 15.Singh Chitra et al ;" design and evaluation of microsphere : a review journal of drug delivery research "; 2013:18-28.
Hemangi Patil. S, Moreshwar Patil. P, Bharat Tekade. W, Vinod Thakare. M and Vijay Patil , Formulation and in vitro Ealuation of Floating Microsphere of Acyclovir.Arch Pharm Science & Res. 2009; 1: 194-198.
Gholap S.B. et al;" Hallow Microsphere: A Review";Brazalian Journal of Pharmaceutical Sciences2010 ; 1(1):74-79.
Praveen Nasa, Sheefali Mahant, Deepika Sharma. Floating Systems: A novel approach towards Gastroretentive Drug Delivery Systems. International Journal of Pharmacy and Pharmaceutical Sciences 2010: 2†3
Nithya Shanthi C et al;`` Traditional and emerging applications of microspheres: A Review. International Journal of Pharm Tech Research’’ 2010; 2(1), 675-681.
.Dutta P. et al ;" Floating Microsphere : Recent Trends in the Development of Gastro Retentive Floating Drug Delivery System"; 2011;4(1).1296-1305.
Singh Prashant et al;`` Biodegradable Polymeric Microspheres As Drug Carriers; A Review Indian Journal Of Novel Drug Delivery’’, 2011;3(2):70-82
Rathore B. et al ;" Microsphere as Drug Delivery Carriers for Management of Diabetic Melllitus , International Journal of Pharmacy and life science"; 2012; 3(10).2064-2070.
Swetha S. Kamath K. et al ;" Design and Evaluation of Floating Microsphere of Rabeprazole Sodium "; 2012; 4(3):357-367.
Mukund Yogesh Jagtap et al ;" Floating Microsphere : A Review"; International Journal of Pharmaceutical S Delivery System: A Review, International Journal of Recent advances in pharmaceutical research "; 2012;2(3):17-30.
.Ramana Jaspreet et al,â€Recent Advances in Floating Microspheres as Gastro Retentive Drug Delivery System :A reviewâ€International Journal of Recent Advances in Pharmaceutical Researchâ€2012;2(3):5-23.
Braatz D. Richard et al;" Mathematical Modelling of Drug Delivery from Automatically Degradable PLGA Microsphere : A Review, Journal of Controlled Release"; 2013:29-37.
Khan Mohd. Shadab et al;" A Review on Nasal Microsphere, international Journal of pharmasciences "; 2014;4(2):496-506.
