SCREENING OF ANTI CANCER AND ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACTS OF ANNONA MURICATA LEAF AND BARK

Abstract

In the present study, an attempt has been made to congregate the traditional, pharmacological studies done on an important medicinal plant Annona muricata, (Family annonaceae). Medicinal plants are the oldest known healthcare agent. Their importance is still growing although it varies depending on the ethnological, medical and historical background of each place. Medicinal plants are also important for pharmacological research and drug development. The methanolic extract of Gordonia obtusa (Theaceae) was evaluated for its effects on growth in MCF-7 breast cancer cell lines using MTT assay. In these cell lines studied, the extract decreased cell viability, inhibited cell proliferation, and induced cell death in a dose dependent manner. The present study demonstrated that methanolic leaf extract of Annona muricatashoeed more anti-cancer activity, compared to its bark extract. The methanolic leaf and bark extracts of Annona muricata was tested for its antibacterial effect successfully showed zone of inhibition against the tested microorganism. The maximum zone of inhibition was shown by the methanolic leaf extract of Annona muricata against Escherichia coli. So it could be a reliable source of potent pharmacophore for treatment of disease like cancer.