INCREASED SERUM NITRITE AND NITRATE LEVELS IN AMPHOTERICIN-B ADMINISTERED ALBINO RATS

Ashoka Kumar C

Abstract


  Amphotericin B (Amp-B) usefulness is associated with a number of toxic cellular effects. We investigated the in-vivo effects of Amp-B on the nitrite (NO-) and nitrate (NO-) levels in the serum of rats administered with 0.5 or 1.5 mg/kg/wt of Amp-B over 4 or 10 weeks (i.v, weekly doses). The rat serum NO-/NOlevels appeared to be enhanced in the Amp-B administered rats compared to the untreated control group of rats and the changes observed were found to be in a dose and time – dependent manner. Based on the results, it is reported that Amp-B by way of enhancing the production of nitric oxide (NO) may contribute for more production of NO end products like NO-/NO- and these intern may be helpful in reducing the fungal affects, since Amp-B is the drug of choice used against fungal infections in clinical trails

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Innoriginal: International Journal of Sciences (ISSN: 2349-7041)

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