FREE RADICAL SCAVENGING POTENTIAL AND ANTIOXIDANT ACTIVITY OF SILVER NANOPARTICLE COUPLED WITH ANDROGRAPHIS PANICULATA (AP-AG NP) AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED TOXICITY IN MICE

Authors

  • Soumendra Darbar Faculty Council of Science Jadavpur University Kolkata-700032, India Contact No. 09477153353
  • Srimoyee Saha Department of Physics, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, India E-mail:Atischatterjee@gmail.com
  • Atiskumar Chattopadhyay Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, India

Abstract

Background: Nanomedicine is a branch of medicine that applies the knowledge and tools of nanotechnology to the prevention and treatment of life threatening disease. Therapeutic exposure to Silver Nanoparticle Coupled with Andrographis paniculata (AP-Ag NP) was assed against CCl4 induced oxidative stress in tissue level. Aims and Objectives: The present study aimed to evaluate the comparative efficacy of AP-Ag NP against Carbon tetrachloride (CCl4) induced oxidative stress. Materials and Methods: Male swiss albino mice were exposed to Carbon tetrachloride (CCl4) for 28 days and were co-administered orally with AP-Ag NP (50 mg/kg each) to evaluate effects on heme synthesis pathway, hepatic oxidative injury and antioxidant potential. Results: The results suggest a significantly elevated ROS, decreased blood and hepatic GSH levels, Superoxide dismutase and Catalase activities after Carbon tetrachloride (CCl4) exposure. Co-administration of Nano-antioxidants (AP-Ag NP) increased SOD, CAT and GSH levels and was also beneficial in the recovery of oxidative injury and restoring inhibited aminolevulinate dehydratase (ALAD) activity. Conclusion: Our results suggest that Silver Nanoparticle Coupled with Andrographis paniculata (AP-Ag NP) have the potential antioxidant effect in mice. Keywords: AgNP; Andrographis paniculata; Protection; Free radicals; Lipid peroxidation.

Author Biographies

Soumendra Darbar, Faculty Council of Science Jadavpur University Kolkata-700032, India Contact No. 09477153353

Faculty Council of ScienceJadavpur University Kolkata-700032, India Contact No. 09477153353

Srimoyee Saha, Department of Physics, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, India E-mail:Atischatterjee@gmail.com

Department of Physics, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, IndiaE-mail:Atischatterjee@gmail.com

Atiskumar Chattopadhyay, Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, India

Faculty of Science, Jadavpur University, Raja S C Mallick Road, Kolkata-700032, India

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Published

2019-11-01

How to Cite

Darbar, S., Saha, S., & Chattopadhyay, A. (2019). FREE RADICAL SCAVENGING POTENTIAL AND ANTIOXIDANT ACTIVITY OF SILVER NANOPARTICLE COUPLED WITH ANDROGRAPHIS PANICULATA (AP-AG NP) AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED TOXICITY IN MICE. Innoriginal: International Journal of Sciences, 1–6. Retrieved from https://innoriginal.com/index.php/iijs/article/view/226