EVALUATION OF POLYHERBAL FORMULATION FOR ITS ANTI-DIABETIC ACTIVITY AGAINST STZ INDUCED DIABETES IN RAT MODEL
Abstract
AbstractIn the present work, anti-hyperglycemic activity of the polyherbal formulation in STZ induced diabetic rats was carried out. The blood glucose level in STZ induced diabetic rats significantly reduced by aq. extract. The polyherbal formulation administered through oral route 500mg/kg body weight. The polyherbal formulation showed potential in their role to reduce the blood glucose level. These herbs may lead to development of more potent anti-diabetic formulation.Keywords: Polyherbal formulation, Anti-diabetic, Streptozotocin, Blood Sugar.References
Davis SN. Insulin, Oral Hypoglycemic Agents and the pharmacology of the Endocrine Pancreas. Goodman and Gilmans the Pharmacological Basis of Therapeutics. Brunton, L.L. (Ed). McGraw-Hill. New York.2006; 1613-1645.
Matsui T. Tanaka T.Tamura S. Toshima A. Alpha glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem.2007;55:99-105
Nagappa AN. Thakurdesai PA et al. Antidiabetic activity of Terminalia Catappa Linn fruits. Journal of Ethnopharmacology. 2003; 88: 45-50.
Murray CJ. Lopez AD. Mortality by cause for eight regions of the world.global burden of disease study. Lancet 1997; 349:1269-76.
G K Mall, P K Mishra, V Prakash. Antidiabetic and hypolipidemic Activity of Gymnema Sylvestre in Alloxan induced Diabetic rats. Global Journal of Biotechnology and Biochemistry. 2009; 4 (1): 37-42.
A.Kumar, R. Ilavarasan, T. Jayachandran, M. Deecaraman, P. Aravindan, N. Padmanabhan and M. Krishan. Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. Jouranl of Medicinal Plants Research. 2008; vol 2 (9): 246-249.
Dr. D. Panday, Dr. GP Rauniar, Dr. K. Panday Momordica Charantia (Karela); an Antidiabetic. World Journal of Pharmacy and Pharmaceutical science. 2014; vol 4, Issue 1, 84-99.
K Shobha and G Patil Antidiabetic Activity of Tinospora Cordifolia (FAM: Menispermaceae) in Alloxan Treated Albino Rats. Applied Research Journal. 2015; Vol 1, Issue 5, 316-319.
S. Hassan, R. Barthwal, M. Nair and S. Haque. Aqueous Bark Extract of Cinnamomum Zeylanicum: A Potential Therapeutic Agent for Streptozotocin-Induced Type 1 Diabetes Mellitus (T1DM) Rats. Tropical Journal of Pharmaceutical Research. 2012; 11(3); 429-435.
A Sharma and N. Singh A Multifarious Potent Herb: Plumbago Zeylanica –A Mini Review. International Journal of Recent Scientific Research. 2015; Vol 6, Issue 6: 4825-4829.
N Trivedi, B Muzumdar J. Bhatt and K Hemavati. Effect of shilajit on blood glucose and lipid profile in alloxan induced diabetic rats. 2004; Vol 36, Issue 6, 373-376.
A Ramachandran. Diabetes and Obesity – the Indian angle. Indian J Med Res 2004;120: 437- 449.
WJ Still, JM Martin, WH Gregor. The effect of alloxan diabetes on experimental atherosclerosis in the rat. Exp Mol Pathol 1964;3:141-7.
R Miller, R Wilson. Atherosclerosis and Myocardial ischemic lesions in alloxan diabetic rabbits fed a low cholesterol diet. Arteriosclerosis 1984;4:586-591.
R Chattopadhyay, M Bandhopadhyay. Effect of Azadirecta indica leaf extract on serum
profile changes in normal and streptozotocin induced diabetic rats. African j Biomed Res
;8:101-4.
