COMPARATIVE STUDY OF DIFFERENT ELECTROCHEMICAL SENSORS FOR POTENTIOMETRIC DETERMINATION OF METOCLOPRAMIDE HYDROCHLORIDE IN BULK POWDER AND IN PHARMACEUTICAL PREPARATION
Abstract
Objective: Development and validation of three electrochemical sensors for determination of metoclopramide hydrochloride (MCP) in its bulk powder and in pharmaceutical preparaion. Methods : The three electrochemical sensors based on the use of metoclopramideــــ phosphomolybdate (MCP-PMA) ion pair as an electroactive material in plasticized PVC membrane, carbon paste and coated graphite sensors. Results: The suggested three-sensors show a near-Nernstian response for MCP over a wide concentration range of 1×10-5-1×10-2 M with detection limits of 8 x10-6 M for PVC and carbon paste sensors and 9×10-6 M for coated graphite sensor. The proposed sensors have a fast response time and can be used for 3-4 weeks without any considerable divergence in potentials. Conclusion: They exhibit comparatively good selectivity with respect to related substances, dosage form additives, alkaline earth and some heavy metal ions, the proposed sensors have been successfully applied for the determination of MCP in its pharmaceutical formulation. Also, the obtained results have been statistically compared to a reported method indicating no significant difference between the investigated methods and the reported one with respect to accuracy and precision. Keywords: Metoclopramide, potentiometry, PVC, carbon paste, coated graphite.References
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