FAST DISSOLVING TABLETS OF ACECLOFENAC: DEVELOPMENT AND OPTIMIZATION

Authors

  • Shivali Singla School of Pharmacy, Abhilashi University
  • Supriya Sharma School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)
  • Suresh Purohit Bhupal Nobles’ College of Pharmacy, Udaipur (Raj.)
  • Himanshu Paliwal Shrinathji College of Pharmacy, Upali Oden, Nathdwara (Raj.)
  • Sachin Goyal School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)

Abstract

Abstract: The present research works was aimed to develope and optimize fast dissolving tablets of aceclofenac via 32 full factorial designs to investigate the influence of formulation variables. Different concentration of crospovidone and mannitol were selected as independent variables. Wetting time and disintegration time were selected as dependent variables. The optimized tablets were then evaluated for various parameters like hardness, friability, disintegration time wetting time. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using optimum concentration of crospovidone and mannitol.Keywords: Fast Dissolving Tablet, Polymer, Solid Dispersion, Dissolution, Disintegration

Author Biographies

Shivali Singla, School of Pharmacy, Abhilashi University

Pharmaceuticds

Supriya Sharma, School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)

School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)

Suresh Purohit, Bhupal Nobles’ College of Pharmacy, Udaipur (Raj.)

Bhupal Nobles’ College of Pharmacy, Udaipur (Raj.)

Himanshu Paliwal, Shrinathji College of Pharmacy, Upali Oden, Nathdwara (Raj.)

3Shrinathji College of Pharmacy, Upali Oden, Nathdwara (Raj.)

Sachin Goyal, School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)

1School of Pharmacy, Abhilashi Univbersity, Chail Chowk, Mandi (H.P.)

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Singla Shivali, Sachin Goyal, Himanshu Paliwal, Mukul Mathur, Chauhan Chetan Singh, Daksh Shashi. Lake color formulation of beet root extract and its optimization. Int J Pharm Sci Rev Res 2016; 40(2): 86-91.

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Supriya Sharma, Shivali Singla, Sachin Goyal, Suresh Purohit, Himanshu Paliwal, Abhishek Soni. Formulation of fast dissolving tablets of aceclofenac by solid dispersion method and evaluation. Assian Journal of Biochemical and Pharmaceutical Research 2017; 4(7): 66-75.

Soni Abhishek, Thakur Hitesh, Singla Shivali, Goyal Sachin. Isolation and characterization of mucilage from Plantago ovate. World J Pharm Life Sci 2017; 3(7): 285-291.

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Published

2018-04-17

How to Cite

Singla, S., Sharma, S., Purohit, S., Paliwal, H., & Goyal, S. (2018). FAST DISSOLVING TABLETS OF ACECLOFENAC: DEVELOPMENT AND OPTIMIZATION. Innoriginal: International Journal of Sciences, 37–41. Retrieved from https://innoriginal.com/index.php/iijs/article/view/149

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Section

RESEARCH ARTICLE