FAST DISSOLVING TABLETS OF ACECLOFENAC: DEVELOPMENT AND OPTIMIZATION
Abstract
Abstract: The present research works was aimed to develope and optimize fast dissolving tablets of aceclofenac via 32 full factorial designs to investigate the influence of formulation variables. Different concentration of crospovidone and mannitol were selected as independent variables. Wetting time and disintegration time were selected as dependent variables. The optimized tablets were then evaluated for various parameters like hardness, friability, disintegration time wetting time. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using optimum concentration of crospovidone and mannitol.Keywords: Fast Dissolving Tablet, Polymer, Solid Dispersion, Dissolution, DisintegrationReferences
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