BIOAVAILABILITY ENHANCEMENT FOR POORLY SOLUBLE DRUGS: A REVIEW

Authors

  • Chinmaya Keshari Sahoo Associate Professor, Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, secunderabad, Telangana-500014
  • G. Santhoshini Reddy UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.
  • Abhignya Vojjala UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.
  • Buchanpally Vikram Reddy UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

Abstract

Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. This present review details about the different approaches used for the enhancement of the solubility of poorly water-soluble drugs. The purpose of this article is to describe the techniques of solubilization for the attainment of effective absorption and improved bioavailability.Keywords: Solubility, bioavailability, absorption, solubilization

Author Biographies

Chinmaya Keshari Sahoo, Associate Professor, Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, secunderabad, Telangana-500014

Associate Professor, Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, secunderabad, Telangana-500014

G. Santhoshini Reddy, UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

Abhignya Vojjala, UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

Buchanpally Vikram Reddy, UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

UG Scholar, Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Telangana, India.

References

Bajaj H,Bisht S,Yadav M,Singh V.Bioavailability enhancement: a review, International Journal of Pharma and Bio Sciences 2011;2(2):202-216

Kumar S,Singh P.Various techniques for solubility enhancement: An overview, The Pharma Innovation Journal 2016; 5(1): 23-28

Hetal T,Bindesh P, Sneha T.A review on techniques for oral bioavailability enhancement of drugs 2010 ;4(3);203-223

Patil MS Sheetal Z.Godse ZS, Saudagar RB. Solubility enhancement by various techniques: an Overview, World journal of pharmacy and pharmaceutical sciences 2013,2(6):4558-4572.

Singh N, Allawadi D,Singh S, Arora SS, Techniques for Bioavailability Enhancement of BCS Class II Drugs: A Review,International Journal of Pharmaceutical and Chemical Sciences 2 (2) 2013,1092-1101.

Sharma D, Soni M, Kumar S, Gupta GD, Solubility Enhancement-Eminent Role in Poorly Soluble Drugs, Research Journal of Pharmacy and Technology.2(2);April-June.2009:220-224.

Nikam SP, A Review: Increasing Solubility of Poorly Soluble Drugs, by Solid Dispersion Technique. Research Journal of Pharmacy and Technology.4(12);Dec.2011:1933-1940.

Vadlamudi MK, Dhanaraj S.Disparate practical way of doing solubility enhancement study to improve the bioavailability of poorly soluble drugs Journal of Chemical and Pharmaceutical Research, 2016, 8(1):208-235

Pardhi D, Shivhare U, Suruse P, Chabra G. Lquisolid Technique For Solubility Enhancement of Poorly Water Soluble Drugs. Research Journal Pharmaceutical Dosage Forms and Technology.2(5);Sept-Oct.2010:314-322.

Lachman L, Lieberman HA, The Theory and Practice of Industrial Pharmacy, CBS

Publication & Distributors Pvt. Ltd. Special Indian Edition 2009: 221.

Md. MofizurRahman, Abul Bashar Ripon Khalipha, Jamal Ahmed, Md. AbShuaibRafshanjani, ShanjidaHaque, Methods of Solubility And Dissolution Enhancement For Poorly Water Soluble Drugs: A Review,1-23.

Pawar AR, Choudhari PD, Novel Techniques For Solubility, Dissolution Rate and Bioavailability Enhancement of Class II & IV drugs, Asian Journal of Biomedical & Pharmaceutical Science(13)2012,9-14.

Varshney HM, Chatterjee A. Solubility Enhancement of Poorly Hydrophilic Drugs by Using Different Newer Techniques: A Review. International Journal of Therapeutic Applications. Volume-6,2012:8-13.

Mukhija U, Soni N, Chawla A, Bhatt DC, Physical Properties and Dissolution Behaviour

of Meloxicam/Poloxamer Solid Dispersions Prepared By Hot Melt Method and Microwave Assisted Method. International Journal of Research In Pharmacy and Science(2)April-june.2012.64-74.

Kumar A, Sahoo SK, Padhe K, Kochar PPS, Satpathy A, Pathak N. Review On Solubility

Enhancement Techniques ForHydrophbic Drugs. PharmacieGlobale International Journal

Of Comprehensive Pharmacy.2(3)2011.1-7.

Vemula VR, Lagishetty V, Lingala S. Solubility Enhancement Techniques. International

Journal of Pharmaceutical Sciences Review and Research(1);Nov-Dec2010:41-51.

Md. Sajid A, Choudhary V. Solubility Enhancement Methods WithImportance of Hydrotropy. Journal of Drug Delivery and Therapeutics(6);2012:96-101.

Patil JS, Kadam DV, Marapur SC, KamalapurMV.Inclusion Complex System; A Novel Technique To Improve The Solubility And Bioavailability Of Poorly Soluble Drugs: A Review. International Journal of Pharmaceutical Sciences Review And Research.2(2);May-June2010.29-34.

Sareen S, Mathew G, Joseph L. Improvement In Solubility of Poor Water-Soluble Drugs By Solid Dispersion. International Journal of Pharmaceutical Investigation: Review Article.2(1);2012:12-17.

Mohanachandran PS, Sindhumol PG, Kiran TS. Enhancement of Solubility and Dissolution Rate: An Overview. PharmacieGlobale International Journal of Compehensive Pharmacy.1(4);2010:1-10.

Doijad RC, Pathan AB, Gaikwad SS, Baraskar SS, Pawar NB, Maske VD. Liquisolid: A Novel Technique For Dissolution Enhancement of Poorly Soluble Drugs. Current Pharma Research. 3(1);2012:735-749.

Chaudhary A, Nagaich U, Gulati N, Sharma VK, Khosa RL. Enhancement of Solubilization and Bioavailability of Poorly Soluble Drugs By Physical and Chemical Modification: A Recent Review. Journal of Advanced Pharmacy Education and Reseach.2(1);2012:32-67.

Thorat YS, Gonjari ID, Homani AH. Soubility Enhancement Techniques: A Review On Conventional and Novel Approaches. International Journal of Pharmaceutical Sciences and Research.2(10);2011:2501-2513.

Hu, J., Johnston, K.P., Williams III, R.O., 2004. Rapid dissolving high potency danazol powders produced by spray freezing into liquid process, Int. J. Pharm. 271, 145–154.

Lipinski, C., 2002. Poor aqueous solubility – an industry wide problem in drug delivery, Am. Pharm. Rev. 5, 82–85.

Dhirendra, K., Lewis, S., Udupa, N.,Atin, K., 2009. Solid dispersions : A Review, Pak. J. Pharm. Sci. 22 (2),234-246.

Chauhan NN, Patel NV, Suthar SJ, Patel JK, Patel MP. Micronization of BCS-II Drugs By Various Approaches For Solubility Enhancement-A Review. Research Journal of Pharmacy and Technology.5(8);Aug.2012:999-1005.

Downloads

Published

2018-06-06

How to Cite

Sahoo, C. K., Reddy, G. S., Vojjala, A., & Reddy, B. V. (2018). BIOAVAILABILITY ENHANCEMENT FOR POORLY SOLUBLE DRUGS: A REVIEW. Innoriginal: International Journal of Sciences, 1–6. Retrieved from https://innoriginal.com/index.php/iijs/article/view/128

Issue

Section

REVIEW ARTICLES