MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES

Abstract

Abstract:Introduction: Simultaneous mathematical determination of rosuvastatin calcium and propranolol hydrochloride using different methods were described. The mathematical determination involves different chemometric models, namely, partial least square (PLS-1) as traditional model and artificial neural network as advanced model with and without variable selection procedure (genetic algorithm). Experimental: A two factor, 5-level experimental design was established resulting in 25 mixtures with variable ratios of the drugs. Thirteen mixtures were used as a calibration set and the last twelve mixtures were used as a validation set to validate the ability of the prediction. Conclusion: The methods were used for quantitative analysis of the drugs in raw materials and pharmaceutical dosage form. The validity of the proposed methods was assessed using the standard addition technique.Keywords: Chemometric technique; partial least squares; genetic algorithm; artificial neural network.