MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES
AbstractAbstract:Introduction: Simultaneous mathematical determination of rosuvastatin calcium and propranolol hydrochloride using different methods were described. The mathematical determination involves different chemometric models, namely, partial least square (PLS-1) as traditional model and artificial neural network as advanced model with and without variable selection procedure (genetic algorithm). Experimental: A two factor, 5-level experimental design was established resulting in 25 mixtures with variable ratios of the drugs. Thirteen mixtures were used as a calibration set and the last twelve mixtures were used as a validation set to validate the ability of the prediction. Conclusion: The methods were used for quantitative analysis of the drugs in raw materials and pharmaceutical dosage form. The validity of the proposed methods was assessed using the standard addition technique.Keywords: Chemometric technique; partial least squares; genetic algorithm; artificial neural network.
How to Cite
Abdel-Fattah, A. (2018). MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES. Innoriginal: International Journal of Sciences, 5–9. Retrieved from https://innoriginal.com/index.php/iijs/article/view/116