MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES

Ashraf Abdel-Fattah

Abstract


Abstract:

Introduction: Simultaneous mathematical determination of rosuvastatin calcium and propranolol hydrochloride using different methods were described. The mathematical determination involves different chemometric models, namely, partial least square (PLS-1) as traditional model and artificial neural network as advanced model with and without variable selection procedure (genetic algorithm). Experimental: A two factor, 5-level experimental design was established resulting in 25 mixtures with variable ratios of the drugs. Thirteen mixtures were used as a calibration set and the last twelve mixtures were used as a validation set to validate the ability of the prediction. Conclusion: The methods were used for quantitative analysis of the drugs in raw materials and pharmaceutical dosage form. The validity of the proposed methods was assessed using the standard addition technique.

Keywords: Chemometric technique; partial least squares; genetic algorithm; artificial neural network.


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Innoriginal: International Journal of Sciences (ISSN: 2349-7041)

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