STABILITY-INDICATING POTENTIOMETRIC METHOD FOR THE DETERMINATION OF CYCLOBENZAPRINE HCL USING TWO CARBON PASTE ION-SELECTIVE ELECTRODES

Nesrin K Ramadan, Azza A Moustafa, Taghreed A Mohamed, Rowayda M Fouad

Abstract


Objective: Two sensitive and selective carbon paste electrodes were developed and investigated for determination of cyclobenzaprine hydrochloride. Methods: Sensor I was developed using ammomium renikate as an anion exchanger and dibutyl phthalate as a plasticizer while sensor II was developed using phosphotungestic acid as an anion exchanger and dibutyl phthalate as a plasticizer. Results: The proposed electrodes showed a near-nernsation response in the range from 1.00×10-4-1.00×10-2 M and 5.00×10-5-1.00×10-2 M for sensor I and sensor II, respectively. The selectivity of the proposed electrodes to a number of interferences was investigated. Conclusion: Cyclobenzaprine hydrochloride was successfully determined in pure form, pharmaceutical formulation and in the presence of anthraquinone (its oxidative degradation product) using the two proposed sensors.

Keywords: Cyclobenzaprine hydrochloride (CB), Ion-Selective Electrodes (ISEs), Carbon Paste, Potentiometry.


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