INTER-INDIVIDUAL VARIATIONS IN TACROLIMUS TREATED PATIENTS WITH RENAL TRANSPLANTS: CASE FOR PHARMACOGENTIC MONITORING
Abstract
Tacrolimus is a widely used drug for renal transplant now a days. In India, it popularity has grown in recent times. One of the important feature of tacrolimus metabolism is that it has wide variation in pharmacokinetcics. Main reasons of pharmacokinetic variations are variations in intestinal and hepatic metabolism. As a result; there are wide intra and inter-patient variations. However, the incidence of these variations is not clearly known. Pharmacogentic monitoring of drugs with unpredictable pharmakinetics could be a new tool towards individualization of drug therapy. It has been known for sometime that inter-individual variations contribute to drug toxicity and inferior transplant outcomes. We were interested in studying the relationship between dose and concentration in Indian patients who underwent renal transplant and to know its implications.Keywords: tacrolimus, ultra-rapid metabolismÂReferences
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