Satinder Kakkar, Namita Prasad, Ramandeep Singh


The aim of this article is to study the buccal patches. Buccal patch is a non dissolving thin matrix modified release dosage form composed of one or more polymer films or layers containing the drug and/or other excipients. Buccal patches have been become an interesting area of novel drug delivery system as the dosage forms designed for buccal administration should not cause irritation and should be small and flexible enough to be accepted by the patientThe study of buccal patches include its introduction, types of buccal patches, advantages, limitation, potential uses of buccal patches, polymer used, methods of preparation, evaluation.

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Parmar HarshadG et al;" Buccal Patches : A Technical Note"; 2012; 029.

M.M.Veillard et al., “Preliminary Studies of Oral Mucosal Delivery of Peptide Drugs,” J. Controlled Release , 1987;1(2):123–131 .

Y. Kurosaki et al., “Effects of Surfactants on the Absorption of Salicylic Acid from Hamster Cheek Pouch as a Model of Keratinized Oral Mucosa,” Int. J. Pharm. 1988;4(7):13-19

Mohd S. Pendelkar et al ;" Formulation and evaluation of bioadhesive patch for buccal delivery of tizanidine, Acta Pharmaceutica Sinica B”; 2012;2(3):318–324

Shinde Pramod et al ;" Buccal Film : An innovative Dosage from Designed to Improve Patient Complaince, international journal of pharmaceutical and chemical sciences. 2012;1 (4):12

Shojaei Amir H., Buccal Mucosa As A Route For Systemic Drug Delivery: A Review, J Pharm PharmaceutSci, 1998;1 (1):15-30

deVries M.E, Ph.D. Thesis, University of Leiden, Leiden, The Netherlands, 1991

P.K. Khobrgade et al ;" Literature studies on preparation and evaluation of buccal patches";2014;25(2):73

Subhranshu Panda et al ;" Development and Characterisation of muccoadhesive patches of glimipride for buccal administration, journal of pharmaceutical science and bioscientific research"; 2011;1(2): 102-107

Mishra S. " A Review article : Recent Approaches in buccal patches, the pharma innovation ";2012;7(2):12

Zhang.J et al, An In Vivo Dog Model for Studying Recovery Kinetics of the Buccal Mucosa Permeation Barrier after Exposure to Permeation Enhancers Apparent Evidence of Effective Enhancement without Tissue Damage, Int. J. Pharm, 1994:15–22.

A.J. Hoogstraate et al., “Diffusion Rates and Transport Pathways of FITC-Labelled Model Compounds through Buccal Epithelium,” Proc. Int. Symp. Contr. Rel. Bioact.Mater. 1993;20:234–235

Bobade Nishan N; "A Review on buccal drug delivery system, International Journal of Pharmacy and Pharmaceutical Science Research "; 2013 ; 3(1):21

A.H. Shojaei, Buccal mucosa as a route for systemic drug delivery: a review, J. Pharm. Pharmaceut. Sci., 1998;1(1): 15-30.

SevdaSenel, Mary Kremer, Katalin Nagy and Christopher Squier, Delivery of Bioactive Peptides and Proteins Across Oral (Buccal) Mucosa, Current Pharmaceutical Biotechnology, 2001; 2: 175-186.

S.K. Gupta, I.J. Singhavi, M. Shirsat, G. Karwani, A. Agrawal, A. Agrawal, Buccal adhesive drug delivery system: a review, Asian J. Biochemical and pharmaceutical research2011;2(1): 105-114.

Amir H, et al, Systemic drug delivery via the buccal mucosal route, Pharmaceutical technology, 2001:127

Steward A et al, The Effect of Enhancers on the Buccal Absorption of Hybrid (BDBB) Alpha Interferon, Int. J. Pharm,1994:145–149

N.G. Raghavendra Rao et al ;" Overview of buccal drug delivery system "; J. Pharm. Sci. & Res.2013;5(4): 80 - 88

.Kumar TP, Desai KG and Kumar SG. Mechanism of buccal permeation enhancers, Indian J. Pharm. Edu., 2002; 36(3):147-15

Prajapati Vivekanand et al;" Mucoadhesivebuccal patches and use of natural polymer in its preparation : A Review; 2012; 4(2):12

Shahidi F., and Synowiecki J., Isolation and characterization of nutrients and value-added products from snow crab (chionoecetesopilio) and shrimp (pandalus borealis) processing discards, J. Agri. and Food Chemi., 1991;39 (8):1527–1532.

Tomolin, J., Taylor J.S., and Read N.W., The effect of mixed faecal bacteria on a selection of viscous polysaccharide in vitro, Nutr. Rep. Int., 1989;3(9):121–13.

Macfarlane G.T., Hay S., Macfarlane S., and Gibson G.R., Effect of different carbohydrates on growth polysaccharidases and glycosidase production of bacteroidesovatus in batch and continuous culture, J. Appl. Bacteriol., 1990, 68,179–187

Satinder Kakar, Ramandeep Singh, Alok Semwal. Transdermal drug delivery as a boon. Asian Pacific Journal of Health Sciences, 2014; 1(1): 13-25

AC Williams, BW Barry. Penetration enhancers.Adv.Drug Del. Rev., 2004, 56: 603-618.

Remminghorst and Rehm, Microbial Production of Alginate: Biosynthesis and Applications. Caister Academic Press. Microbial Production of Biopolymers and Polymer Precursors. 2009;1(2):9

S. Himabindu et al ;" Formulation and invitro evaluation of muccoadhesivebuccal patches of cyproheptadine hydrochloride, journal of applied pharmaceutical science "; 2012;2(7):13

B.J. Aungst and N.J. Rogers, “Site Dependence of Absorption- Promoting Actions of Laureth-9,Na Salicylate,Na2EDTA, and Aprotinin on Rectal,Nasal, and Buccal Insulin Delivery,” Pharm. Res. 1988;5 (5):305–308

Radha Madhavi et al;" Buccal film drug delivery system : An innovative and emerging technology- molecular pharmaceutics and organic process research";2013,1(3):19

Naresh Kshirasagar et al;" Design and evaluation of chitosan containing mucco adhesive buccal patch of fluxotine hydrochloride";2012,2(6):15


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