EDEMA REDUCING PROSPECTIVE OF MURRAYANINE BASED CHALCONE COMPOUND AS EMERGING NSAID AGENT
Abstract
In this study substituted murrayanine based chalcone compound (E)-3-(5-chloro-2-hydroxy-4-methylphenyl)-1-(1-methoxy-9H-carbazol-3-yl)prop-2-en-1-one has been synthesized by conventional method and screened for in vivo anti-inflammatory activity in Swiss albino rats employing the carrageenan-induced paw edema method. The synthesized compound was characterized by spectroscopic techniques (FT-IR; 1H-NMR; and Mass) and elemental analyses. The compound displayed % edema reduction of 24.91%, 34.49%, and 51.31%, respectively in the carrageenan-induced paw edema method over the 3 hrs duration. The molecule presented a fairly significant activity owing to inhibition of the inflammatory mediators like cyclooxygenase-1/2 (COX-1/2) and lipoxygenase (LOX) through the various electron-donating and electron-withdrawing substituents present in the B-ring of the chalcone scaffold. The activity was not analogous with that of the standard drug indomethacin which exhibited 74.59% in the third hr which indicated that still much improvement is needed for the development of better anti-inflammatory candidates. The study will undoubtedly motivate the researchers working on pharmacologically active low-molecular-weight ligands in the better and rational development of the molecules.References
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