STABILITY-INDICATING POTENTIOMETRIC METHOD FOR THE DETERMINATION OF CYCLOBENZAPRINE HCL USING TWO CARBON PASTE ION-SELECTIVE ELECTRODES

Authors

  • Nesrin K Ramadan Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt
  • Azza A Moustafa Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt
  • Taghreed A Mohamed Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt
  • Rowayda M Fouad Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt

Abstract

Objective: Two sensitive and selective carbon paste electrodes were developed and investigated for determination of cyclobenzaprine hydrochloride. Methods: Sensor I was developed using ammomium renikate as an anion exchanger and dibutyl phthalate as a plasticizer while sensor II was developed using phosphotungestic acid as an anion exchanger and dibutyl phthalate as a plasticizer. Results: The proposed electrodes showed a near-nernsation response in the range from 1.00×10-4-1.00×10-2 M and 5.00×10-5-1.00×10-2 M for sensor I and sensor II, respectively. The selectivity of the proposed electrodes to a number of interferences was investigated. Conclusion: Cyclobenzaprine hydrochloride was successfully determined in pure form, pharmaceutical formulation and in the presence of anthraquinone (its oxidative degradation product) using the two proposed sensors.Keywords: Cyclobenzaprine hydrochloride (CB), Ion-Selective Electrodes (ISEs), Carbon Paste, Potentiometry.

Author Biographies

Nesrin K Ramadan, Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt

Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt

Azza A Moustafa, Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt

Department Analytical Chemistry, Faculty of Pharmacy, Cairo University, Giza, Egypt

Taghreed A Mohamed, Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt

Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt

Rowayda M Fouad, Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt

Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research, 9 Abou-Hazem str, Giza, Egypt

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Published

2018-11-03

How to Cite

K Ramadan, N., A Moustafa, A., A Mohamed, T., & M Fouad, R. (2018). STABILITY-INDICATING POTENTIOMETRIC METHOD FOR THE DETERMINATION OF CYCLOBENZAPRINE HCL USING TWO CARBON PASTE ION-SELECTIVE ELECTRODES. Innoriginal: International Journal of Sciences, 18–24. Retrieved from https://innoriginal.com/index.php/iijs/article/view/210

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RESEARCH ARTICLE