DEVELOPMENT AND OPTIMIZATION OF HYDRODYNAMICALLY BALANCED GASTRORETENTIVE FLOATING TABLETS OF ATENOLOL

Authors

  • Arun Raj Department of Pharmaceutical Sciences, Mahatma Gandhi University RIMSR, Kottayam, Kerala, India.

Abstract

The present work was aimed to develop a floating drug delivery system of Atenolol based on novel approaches and to investigate there In vitro drug release and buoyancy performance. The interaction between the excipcents and Atenolol was also studied through FTIR spectroscopy.  Tablets were then prepared by direct compression technique using different combinations of polymers. All the formulations were analyzed for pre-compression and post-compression parameters. The pre-compression and post-compression parameters of all the formulations were within the required and acceptable limit. From the in-vitro buoyancy studies the floating lag time and duration of buoyancy were found to be satisfied.  In vitro drug release studies revealed that F3 shows much higher dissolution rate. In vitro release data were fitted to various kinetic models. The mechanism of drug release from tablets was found to be non-Fikian, anomalous transport. Results from various evaluations suggested that matrix type Atenolol floating tablets could be used as hydrodynamically balanced gastroretentive floating drug delivery devices.Keywords: Floating drug delivery, Atenolol, Hydrodynamically balanced, Gastro retentive. 

Author Biography

Arun Raj, Department of Pharmaceutical Sciences, Mahatma Gandhi University RIMSR, Kottayam, Kerala, India.

Lecturer,Department of Pharmaceutical Sciences, Mahatma Gandhi University RIMSR, Kottayam, Kerala, India.

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Published

2015-01-01

How to Cite

Raj, A. (2015). DEVELOPMENT AND OPTIMIZATION OF HYDRODYNAMICALLY BALANCED GASTRORETENTIVE FLOATING TABLETS OF ATENOLOL. Innoriginal: International Journal of Sciences. Retrieved from https://innoriginal.com/index.php/iijs/article/view/18

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Section

RESEARCH ARTICLE