ELECTROCHEMICAL DETERMINATION OF AMLODIPINE BESILATE AND BENAZEPRIL HYDROCHLORIDE IN THEIR BINARY MIXTURE USING PVC AND COATED GRAPHITE SENSORS
Abstract
Objective—Design and prepare two ion selective electrodes, Amlodipine–PVC sensor and Benazepril–coated graphite sensor for determination of amlodipine besilate and benazepril hydrochloride in their binary mixture. Methods— The sensors design is based on the ion pair of amlodipine besilate or benazepril hydrochloride with sodium tetraphenylborate using dioctylphthalate as a plasticizer. Results— Under the optimum conditions, the proposed sensors shows the slopes of 28.400 and 58.500 mV per concentration decade in the concentration range of 10-5 – 10-2 for amlodipine besilate and benazepril hydrochloride, respectively . The sensors exhibit a very good selectivity for the studied drugs with respect to a large number of interfering ions. The sensor enables determining the studied drugs in their binary mixtures with good percent recovery of each drug which indicates the higher selectivity of the prepared sensors. Conclusion—The sensors were successfully used for potentiometric determination of amlodipine besilate and benazepril hydrochloride in pure solutions and in their combined dosage form.References
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