A REVIEW ON PHYTOCHEMISTRY AND PHARMACOLOGICAL ASPECTS OF DERRIS SCANDENS (ROXB.) BENTH.

Ramya Madhiri, Dr. Jagadeesh Panda

Abstract


Objective:
Traditional and Herbal medicines were very important and play vital role. Scientific research was trending of the isolation of active compounds of herbal origin . The secondary metabolites have prominent therapeutic effect like treatment for musculoskeletal pain, antimicrobial , antioxidant effects so in the present review study was based on the overall significance of active constituents, pharmacological aspects , identification tests for active constituents were discussed in which the one can review all the important information and the research done in the Derris scandens Benth which may be helpful for the future research work.

Conclusion : It may remain as the fundamental source of chemical diversity and an important source of drug discovery. This study highlights the bioactive metabolites produced by Derris scandens.

Keywords: Secondary metabolites, Diversity ,anti-inflammatory, antimicrobial, antioxidant,
anticancer

 


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References


Mahabusukaram .W et.al (2004 )A Benziland isoflavone derivatives from Derris scandens Benth PMID; 15110702

Thothathari.K (1961) studies on leguminosae .A Taxanomic revision of the genus Derris scandens in India Bulletein of botanical survey of india 3(2)175-200.

Vijay malik(2015) Nature conservation status of assessment of Derris scandens . International journal of plant sciences ISSN: 2319-3824,Vol 4(1)JAN ,

Plant encyclopedia of life.

pubchem.ncbi.nlm.nih.gov › compound

Komal kumar. J (2012,) PhD student Department of Environmental Science,University of Mysore, Manasagangothri, Karnataka, India- 570006 .Journal of Pharmacy Research Vol.5 Issue 6.June 2012J Komal Kumar et al. / Journal of Pharmacy Research 5(6),3059-3062 3059-3062 Research ArticleISSN: 0974-6943

Puttarak P, Sawangjit R, Chaiyakunapruk N. Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: A Systematic Review and Meta-analysis of randomized controlled trials. J Ethnopharmacol. 2016 Sep 9. pii: S0378-8741(16)30755-3. doi: 10.1016/j.jep.2016.09.021.

Vilai.Kuptniratsaikul.Asst prof ,The study by its ClinicalTrials.gov identifier (NCT number): NCT00503828, Department of Rehabilitation Medicine,Faculty of Medicine ,Siriraj Hospital.

Brownson DM, Azios N G, Fuqua BK, Dharmawardhane SF, Mabry TJ (2002). Flavonoid effects relevant to cancer. J Nutr, 132, 3482-9.

Habr-Gama A, Perez RO, Sao Juliao GP, Proscurshim I, Gama- Rodrigues J (2010). The need for effective radiosentitizing agents: experience in patients with complete pathological response. Anticancer Drugs, 22, 308-10.

Kastan MB, Bartek J (2004). Cell-cycle checkpoints and cancer. Nature, 432, 316-23.

Kuptniratsaikul V, Pinthong T, Bunjob M, et al (2011). Efficacy and safety of Derris scandens Benth extracts in patients with knee osteoarthritis. J Altern Complement Med, 17, 147-53

Laupattarakasem P, Houghton PJ, Hoult JR (2004). Anti-inflammatory isoflavonoids from the stems of Derris scandens. Planta Med, 70, 496-501

Mahabusarakam W, Deachathai S, Phongpaichit S, Jansakul C, Taylor WC (2004). A benzil and isoflavone derivatives from Derris scandens Benth. Phytochemistry, 65, 1185-91.

Maurya DK, Devasagayam TP, Nair CK (2006). Some novel approaches for radioprotection and the beneficial effect of natural products. Indian J Exp Biol, 44, 93-114.

Pisamai Laupattarakasem BS, Wiroon Laupattarakasem (2007). Antimigration of cancer cells by derris scandens on cholangiocarcinoma cells. Srinagarind Med J, 22, 339-45

Rukachaisirikul V, Sukpondma Y, Jansakul C, Taylor WC (2002). Isoflavone glycosides from Derris scandens. Phytochemistry, 60, 827-34.

Puttarak P, Sawangjit R, Chaiyakunapruk N.( 2016 )Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: A Systematic Review and Meta-analysis of randomized controlled trials. J Ethnopharmacol. Sep 9. pii: S0378-8741(16)30755-3. doi: 10.1016/j.jep.2016.09.021.

T. Sreelatha, A. Hymavathi, V.R.S. Rao, P. Devanand, P.U. Rani, J.M. Rao, K.S. Babu(2010), A new benzil derivative from Derris scandens: structure-insecticidal activity studyBioorg. Med. Chem. Lett., 20 pp. 549-553.

Mon, MM., Maw, SS., OoZK,(2011) Quantitative Determination of Free Radical Scavenging Activity and Anti-tumor Activity of omeMyanmar Herbal Plants. World academy of science, engineeringand technology.

Tedasen A, Sukrong S, Sritularak B, Srisawat T, Graidist P.(2016) 5,7,4′-Trihydroxy-6,8-diprenylisoflavone and lupalbigenin, active components of Derris scandens, induce cell death on breast cancer cell lines. Biomed Pharmacother. 2016Jul;81:235-41. doi: 10.1016/j.biopha.2016.03.044.

E.P Clark Scandenin a constituent of the roots of Derris scandens Journal of organic chemistry vol 08 issuew 5 pages 489 -492.

C.sittiwet and D.Puangpronpitag (2009) Antimicrobial properties of Derris scandens aqueous exract, Journal of biological sciences volume 9 (6);607-611 .

Suphattra sangmalee et.al Bioassayed guided isolation of two flavonoids from Derris scandens with Topoisomerase ii poison activity .Biological and pharmaceutical Bulletin ISSN 1347-5215 vol 39(2016)issue 4 pages 631-635.

Kamonthip Jutathis et.al (2016) An enzyme linked immunosorbent assay for Genistein .Determination in Derris scandens using a polyclonal antibody .Wiley online library vol 27,issue 6,Dec 2016 pages 336-342.


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