A REVIEW ON LIQUISOLID TECHNOLOGY

Arun Raj, Sreerekha S

Abstract


This review discusses, out of several techniques available, liquisolid system to improve dissolution rate of water insoluble drugs and to enhance dissolution rate of water soluble drugs. The limited solubility of drugs is the challenging issue for industry during development of the ideal solid dosage unit. Liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. The technique is based upon the admixture of drug loaded solutions (or) liquid drug with appropriate carrier (microcrystalline cellulose, starch, lactose) and coating material (silica gel). The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Liquid drugs can be mixed directly with carriers to produce liquisolid systems. Liquisolid systems can be used to either enhance or retard drug release.

Keywords: Liquisolid compacts, Dissolution rate, Liquid loading factors and poorly water-soluble drugs.


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