AN UPDATED PHARMACOLOGICAL OVERVIEW ON MOMORDICA CYMBALARIA (ATHALAKKAI)”

Authors

  • GOPALASATHEESKUMAR K KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India.

Abstract

The review was carried out to discuss in detail about pharmacological activities of Momordica cymbalaria. Momordica cymbalaria is belongs to the family of Cucurbitaceae. In this plant vegetables are used for food in southern countries. The phytoconstituents of alkaloids, carbohydrates, flavonoids, sterols, terpenoids and saponins are present in Momordica cymbalaria. In this review evaluate the various pharmacological activities of the Momordica cymbalaria. From the literature collections the Momordica cymbalaria was having the Anti-diabetic Activity, Hypolipidemic activity, Anti-diarrhoeal activity, Antiulcer activity, Neuroprotective Activity, Cardioprotective Effects, Hepatoprotective activity, Nephroprotective, Anti-Cancer Activity, Anticonvulsant activity, Anti-inflammatory activity, antiovulatory, abortifacient activity and Antimicrobial Properties.Key words: In vivo, Anti-diabetic, Saponins, Flavanoids, Animal model, Phytochemical 

Author Biography

GOPALASATHEESKUMAR K, KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India.

KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India.

References

Suman Samaddar, Raju Koneri Balwanth, Abhinaya Bhattarai, Chandrasekhar KB. In Vitro Glucose Uptake Activity of an Oleanane-Type Triterpenoid Saponin Isolated from Momordica Cymbalaria. Indo American Journal of Pharmaceutical Research. 2015; 5(05): 2071-2077

Pramod Kumar, Devala Rao G, Lakshmayya, Ramachandra Setty S. GC-MS Analysis and Antiulcer Activity of Ethanol Extract of Tubers of Momordica tuberosa Cogn. (Cucurbitaceae) in Rats. J App Pharm. 2011; 04(03):359-369

Suman Samaddar, Raju Koneri Balwanth, Abhinaya Bhattarai, Chandrasekhar KB. Oleanane-Type Triterpenoid Saponin of Momordica Cymbalaria Exhibits Neuroprotective Activity in Diabetic Peripheral Neuropathy by Affecting the Polyol Pathway. International Journal of Pharmaceutical Sciences and Research. 2016; 7(2):618-625.

Jeevanantham P, Vincent S, Balasubramaniam A, Jayalakshmi B, Senthil Kumar N. Anti-inflammatory activity of Methanolic Extract of Aerial parts of Momordica cymbalaria Hook F. 2011; 2(9):2399-2402

Mukumbayi P Mulumba, Raju Koneri, Suman Samaddar. Cardioprotective Effects of Saponin Momordica cymbalaria in Ischemia Reperfusion Injury. International Journal of Pharmacy Review and Research. 2015; 5(4):385-390

Yasmeen A Maniyar, Jayapradha Shivanand Totad. Evaluation of anticonvulsant activity of ethanolic extract of Momordica tuberosa leaves in experimental animal. International Journal of Basic and Clinical Pharmacology. 2015; 4(6):1091-1094

Nagarathana PKM, Sanjib Kumar Yadav, Satish P, Dipendra Sah. Protective role of Momordica cymbalaria in diethyl nitrosamine induced hepatocellular carcinoma. International Journal of Pharmacological Research. 2016; 6(01):7-12

Suman Samaddar, Raju Koneri Balwanth, Sunil Kumar Sah, Chandrasekhar KB. Protective Effect of Saponin of Momordica Cymbalaria Fenzl on High-Glucose Induced Neuropathy in Nb-41a3 Mouse Neuroblastoma Cells. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8(4):229-235

Pramod Kumar, Devala Rao G, Lakshmayya, Ramachandra Setty S. Nephroprotective and Nitric oxide Scavenging Activity of Tubers of Momordica tuberosa in Rats. Avicenna Journal of Medical Biotechnology. 2011; 3(2):87-93

Dhasan PB , Jegadeesan M, Kavimani S. Antiulcer activity of aqueous extract of fruits of Momordica cymbalaria Hook f. in Wistar rats. Pharmacognosy Res. 2010; 2(1):58-61

Mukumbayi P. Mulumba, Raju Koneri, Suman Sammadar. Antihypercholesterolemic Mechanism of Saponins of Momordica Cymbalaria and Momordica Dioica. European Journal of Biomedical and Pharmaceutical sciences. 2015; 2(6):279-287

Vrushabendra Swamy B, Jayaveera K, Ravindra Reddy K, Bharathi T. Anti-diarrhoeal activity of fruit extract of Momordica cymbalaria Hook. F. The Internet Journal of Nutrition and Wellness. 2007; 5(2):1-6

Jeevanantham P , Vincent S, Balasubramaniam A, Jayalakshmi B, Senthil Kumar N. Anti Cancer Activity of Methanolic Extract of Aerial parts of Momordica cymbalaria Hook F. Against Ehrlich Ascites Carcinoma in Mice. J. Pharm. Sci. & Res. 2011; 3(8):1408-1411

Kumar P, Devala Rao G, Lakshmayya, Setty S Ramachandra. Ethanol Extract of Momordica Tuberosa Tubers Protects Liver In Paracetamol-Induced Damage Archives of Biological Sciences, Belgrade. 2010; 62(4):999-1003

Vrushabendra Swamy BM, Jayaveera KN. Antimicrobial Properties of Momordica cymbalaria Hook. F. Pharmacologyonline. 2007; 3: 505-510

Firdous M, Koneri R, Sarvaraidu CH, Harish M, Shubhapriya KH Niddm. Anti-diabetic activity of Saponins of Momordica cymbalaria in Streptozotocin- Nicotinamide NIDDM Mice. Journal of Clinical and Diagnostic Research. 2009; 3:1460-1465.

Shrivardhan V Balkhande, Babasaheb S Surwase. Antimicrobial Activity of Tuberous Root Extracts of Momordica Cymbalaria Hook. Asian Journal of Pharmaceutical and Clinical Research. 2013; 6(1):201-203.

Koneri RB, Samaddar S, Ramaiah CT. Antidiabetic activity of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl. Indian J Exp Biol. 2014; 52(1):46-52

Rao BK , Kesavulu MM, Giri R, Appa Rao C. Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook. fruit powder in alloxandiabetic rats. J Ethnopharmacol. 1999; 67(1):103-109

Puttanarasaiah Mahesh Kumar, Marikunte V Venkataranganna, Kirangadur Manjunath, Gollapalle L Viswanatha, Godavarthi Ashok. Methanolic Fruit Extract of Momordica Cymbalaria Alleviates Insulin Resistance by Enhancing Expression of Adiponectin and Leptin In Vitro. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5(6):1925-1935

Palanivel V, Mohammed Shafi, Senthil Kumar KL. Antidiabetic and Hypolipidemic activities of momordica tuberosa unripe fruit extract on diabetic induced rats. Int J Adv Pharm Gen Res. 2013; 1(2):33-40

Kameswararao B, Kesavulu MM, Apparao C. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan diabetic rats. Fitoterapia. 2003; 74(12):7-13

Koneri R, Balaraman R, Saraswati CD. Antiovulatory and Abortifacient activity of the ethanolic extract of roots of Momordica cymbalaria Fenzl. In rats. Indian J Pharmacol. 2006; 38(2):111-114

Rajasekhar MD, Badri KR, Vinay Kumar K, Babu KR, Fatima SS, Sampath Kumar MT, Appa Rao C. Isolation and characterization of a novel antihyperglycemic protein from the fruits of Momordica cymbalaria. J Ethnopharmacol. 2010; 128(1):58-62

Yeddula Ezra, Syed Muneer, Mohammad Mansoor, Srinivasa Rao D. In vitro antioxidant and hypolipidemic activity of Momordica cymbalaria Fenzl in wistar rats. Journal of Pharma Research. 2014; 3(8):172-175

Puttanarasaiah Mahesh Kumar, Marikunte V Venkataranganna, Kirangadur Manjunath, Gollapalle L Viswanatha, Godavarthi Ashok. Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4. Chinese Journal of Natural Medicines. 2014; 12(12):895-900

Koneri RB , Samaddar S , Simi SM , Rao ST. Neuroprotective effect of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl in diabetic peripheral neuropathy. Indian J Pharmacol. 2014; 46(1):76-81

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Published

2017-12-30

How to Cite

K, G. (2017). AN UPDATED PHARMACOLOGICAL OVERVIEW ON MOMORDICA CYMBALARIA (ATHALAKKAI)”. Innoriginal: International Journal of Sciences, 28–31. Retrieved from https://innoriginal.com/index.php/iijs/article/view/117

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